The parasitic tapeworms, for example, can reach lengths of several meters and grow much more quickly than tissues in humans and other complex animals. Many worms have remarkable abilities to regrow and repair their bodies. Together, the head and neck tissues provide extrinsic cues that regulate stem cells, enabling region-specific regeneration in this parasite. Instead, lethally irradiated tapeworms can be rescued when cells from either regeneration-competent or regeneration-incompetent regions are transplanted into the neck. We find no evidence that stem cells are restricted to the regeneration-competent neck. Using transcriptomic analyses and RNA interference, we characterize and functionally validate regulators of tapeworm growth and regeneration. Using the rat intestinal tapeworm, Hymenolepis diminuta, we find that regenerative potential is regionally limited to the neck, where head-dependent extrinsic signals create a permissive microenvironment for stem cell-driven regeneration. Their remarkable growth and regeneration are fueled by adult somatic stem cells that have yet to be characterized molecularly. ![]() To propagate they shed large parts of their body to replace these lost tissues they regenerate proglottids (segments) as part of normal homeostasis. ![]() Tapeworms grow at rates rivaling the fastest-growing metazoan tissues.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |